The mutant mouse strains Junbo ( Mecom Jbo/+) and Jeff ( Fbxo11 Jf/+) develop chronic otitis spontaneously Mecom Jbo/+ mice have highly cellular neutrophil (90%) rich bulla exudates whereas Fbxo11 Jf/+ mice have low cellularity serous effusions (5% neutrophils) indicating differing demand for neutrophil recruitment. We report trans-cortical vessels in the mouse temporal bone connect to the bulla mucosal vasculature and potentially represent a means to recruit myeloid cells directly into the inflamed bulla. In experimental models of stroke and aseptic meningitis there is preferential recruitment of myeloid cells (neutrophils and monocytes) from the marrow in skull flat bones. Skull flat bones have trans-cortical vessels which are responsible for the majority of blood flow in and out of the bone. Chronic otitis media with effusion is the most common cause of childhood deafness and is characterised by effusion of white blood cells into the auditory bulla cavity. 6Centre for Comparative Pathology, Division of Pathology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United KingdomĬhronic otitis media, inflammation of the middle ear, is a sequel to acute otitis media in ∼8% of children.5Division of Pathology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.4Veterinary Pathology, The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Scotland, United Kingdom.3Department of ENT, Royal Sussex County Hospital, Brighton, United Kingdom.2Brighton and Sussex Medical School, Brighton, United Kingdom.1Developmental Biology Division, Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Bhutta 2,3 Jorge Del-Pozo 4 Elspeth Milne 4 Michael Cheeseman 1,5,6*
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